Novel N'-substituted benzylidene benzohydrazides linked to 1,2,3-triazoles: potent α-glucosidase inhibitors.

ABSTRACT: Herein, various N'-substituted benzylidene benzohydrazide-1,2,3-triazoles were designed, synthesized, and screened for their inhibitory activity toward α-glucosidase. The structure of derivatives was confirmed using ¹H- and ¹³C-NMR, FTIR, Mass spectrometry, and elemental analysis. All derivatives exhibited good inhibition with IC₅₀ values in the range of 0.01 to 648.90 µM, compared with acarbose as the positive control (IC₅₀ = 752.10 µM). Among them, compounds 7a and 7h showed significant potency with IC₅₀ values of 0.02 and 0.01 µM, respectively. The kinetic study revealed that they are noncompetitive inhibitors toward α-glucosidase. Also, fluorescence quenching was used to investigate the interaction of three inhibitors 7a, 7d, and 7

SUBMITTER: Saeedi M 

PROVIDER: S-EPMC10235848 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature