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Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors.

ABSTRACT: α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a-m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC50 = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC50 = 750.0 µM). Through kinetic analysis, it was revealed that compound 5k exhibited a competitive inhibition pattern against α-glucosidase. To gain insights into the interactions between the title compounds and α-glucosidase molecular docking was employed. The obtained results highlighted crucial interactions that contribute to the inhibitory activities of the compounds against α-glucosidase. These derivatives show immense potential as promising starting points for developing novel α-glucosidase inhibitors.

SUBMITTER: Ganjeh MS 

PROVIDER: S-EPMC10978946 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors.

Ganjeh Mina Sadeghi MS   Mazlomifar Ali A   Shahvelayti Ashraf Sadat AS   Moghaddam Shiva Khalili SK  

Scientific reports 20240328 1

α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a-m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC<sub>50</sub> = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC<sub>50</sub> = 750.0 µM). Through kinetic analysis, it was revealed that  ...[more]

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