Microwave-assisted synthesis of [⁵²Mn]Mn-porphyrins: Applications in cell and liposome radiolabelling.

ABSTRACT:

Background

Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and as paramagnetic MRI contrast agents. The affinity of porphyrins for lipid bilayers also makes them candidates for cell/liposome labelling. We hypothesised that metalation with the positron emission tomography (PET) radionuclide ⁵²Mn (t_1/2 = 5.6 d) would allow long-term in vivo biodistribution studies of Mn-porphyrins, as well as a method to label and track cells/liposomes, but methods for fast and efficient radiolabelling are lacking.

Results

Several porphyrins were produced and radiolabelled by addition to neutralised [⁵²Mn]MnCl₂ and heating using a microwave (MW) synthesiser, and compared

SUBMITTER: Gawne PJ 

PROVIDER: S-EPMC10236072 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature