Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia.

ABSTRACT:

Background

There is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role in the process of myocardial ischemia (MI) and ischemic stroke (IS). To further explore the common protective mechanism after cardiac and cerebral ischemic injuries, the relationship between GLU receptor-related genes and MI and IS were analyzed.

Results

A total of 25 crosstalk genes were identified, which were mainly enriched in the Toll-like receptor signaling pathway, Th17 cell differentiation, and other signaling pathways. Protein-protein interaction analysis suggested that the top six genes with the most interactions with shared genes were IL6, TLR4, IL1B, SRC, TLR2, and CCL2. Immune infiltration analysis suggested that imm

SUBMITTER: Liao W 

PROVIDER: S-EPMC10239159 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature