Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism.

ABSTRACT:

Objective

Roux-en-Y gastric bypass surgery (RYGB) is among the most effective therapies for obesity and type 2 diabetes, and intestinal adaptation is a proposed mechanism for these effects. It was hypothesized that intestinal adaptation precedes and relates to metabolic improvement in humans after RYGB.

Methods

This was a prospective, longitudinal, first-in-human study of gene expression (GE) in the "Roux limb" (RL) collected surgically/endoscopically from 19 patients with and without diabetes. GE was determined by microarray across six postoperative months, including at an early postoperative (1 month ± 15 days) time point.

Results

RL GE demonstrated tissue remodeling and metabolic reprogramming, including increased glucose and amino acid use. RL GE signatures were e

SUBMITTER: Stefater-Richards MA 

PROVIDER: S-EPMC10240542 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature