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Thromboinflammatory challenges in stroke pathophysiology.

ABSTRACT: Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon stroke. Similarly, the relevance of platelets and their tight crosstalk with a variety of immune cells highlights the relevance of this cell-cell interaction during microvascular dysfunction, neovascularization, and cellular adhesion. Ultimately, we provide an up-to-date overview of therapeutic approaches mechanistically targeting thromboinflammation currently under clinical translation, especially focusing on phase I to III clinical trials.

SUBMITTER: Szepanowski RD

PROVIDER: S-EPMC10241149 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Thromboinflammatory challenges in stroke pathophysiology.

Szepanowski R D RD Haupeltshofer S S Vonhof S E SE Frank B B Kleinschnitz C C Casas A I AI

Seminars in immunopathology 20230501 3

Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., ne ...[more]

PMID: 37273022

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Dataset Information

Thromboinflammatory challenges in stroke pathophysiology.

Publications

Thromboinflammatory challenges in stroke pathophysiology.

Similar Datasets

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