Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer.

ABSTRACT:

Background

The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated.

Methods

TB and MCNS were analysed digitally in 1 and 10 high-power fields (HPF) of 331 HPV-positive and HPV-negative cases from TCGA. Optimising the cutpoints a new cellular dissociation grading (CDG) system was defined and compared to the WHO grading and the Brandwein-Gensler (BG) risk model.

Results

The two-tiered CDG system based solely on TB yielded optimal prognostic stratification with shortene

SUBMITTER: Stogbauer F 

PROVIDER: S-EPMC10241901 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature