The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice.

ABSTRACT: The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug self-administration behavior in mice. Here, we profile the composition of the naïve microbiome and its response to cocaine sensitization in two collaborative cross (CC) strains. These strains display extremely divergent behavioral responses to cocaine sensitization. A high-responding strain, CC004/TauUncJ (CC04), has a gut microbiome that contains a greater amount of Lactobacillus than

SUBMITTER: Tran TDB 

PROVIDER: S-EPMC10242200 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature