The renal resistive index is associated with microvascular remodeling in patients with severe obesity.

ABSTRACT:

Background

Renal hemodynamics is impaired since the early stage of cardiometabolic disease. However, in obesity, its noninvasive ultrasound assessment still fails to provide pathophysiologic and clinical meaningfulness. We aimed to explore the relationship between peripheral microcirculation and renal hemodynamics in severe obesity.

Methods

We enrolled fifty severely obese patients with an indication for bariatric referring to our outpatient clinic. Patients underwent an extensive reno-metabolic examination, paired with Doppler ultrasound and measurement of the renal resistive index (RRI). On the day of the surgery, visceral fat biopsies were collected to perform an ex-vivo complete microcirculatory assessment. Media-to-lumen ratio (M/L) and vascular response to acetylcholin

SUBMITTER: Moriconi D 

PROVIDER: S-EPMC10242520 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature