Comprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis.

ABSTRACT:

Background

Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, the underlying molecular mechanisms remain unclear. This study aims to identify pivotal molecular mechanisms related to ERS in UC pathogenesis and provide novel therapeutic targets for UC.

Methods

Colon tissue gene expression profiles and clinical information of UC patients and healthy controls were obtained from the Gene Expression Omnibus (GEO) database, and the ERS-related gene set was downloaded from GeneCards for analysis. Weighted gene co-expression network analysis (WGCNA) and differential expression analysis were utilized to identify pivotal modules and genes associated with UC. A consensus clustering algorithm was used to classify UC patients. T

SUBMITTER: Deng B 

PROVIDER: S-EPMC10243217 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature