The retina-specific basigin isoform does not induce IL-6 expression in mouse monocytes.

ABSTRACT:

Purpose

Basigin gene products are positioned on adjacent cell types in the neural retina and are thought to compose a lactate metabolon important for photoreceptor cell function. The Ig0 domain of basigin isoform 1 (basigin-1) is highly conserved throughout evolution, which suggests a conserved function. It has been suggested that the Ig0 domain has proinflammatory properties, and it is hypothesized to interact with basigin isoform 2 (basigin-2) for cell adhesion and lactate metabolon formation. Therefore, the purpose of the present study was to determine whether the Ig0 domain of basigin-1 binds to basigin-2 and whether the region of the domain used for binding is also used to stimulate interleukin-6 (IL-6) expression.

Methods

Binding was assessed using recombinant proteins

SUBMITTER: Solstad AD 

PROVIDER: S-EPMC10243675 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature