Primary targeted medical therapy for management of bilateral head and neck lymphatic malformations in infants.

ABSTRACT:

Objectives

Patients born with bilateral head and neck lymphatic malformations (BHNLMs) often require multiple invasive treatments, including tracheostomy. We hypothesized that primary targeted medical therapy (pTMT) with diagnostic needle aspiration reduces the need for invasive therapy such as surgical resection and/or sclerotherapy.

Methods

Retrospective case review was performed of infants with BHNLMs (Grade 2 or De Serres stage IV and V) treated only at our institution from 2000 to 2021. Patients were divided into two cohorts: those managed with pTMT and those managed with observation, sclerotherapy, or surgical intervention (non-pTMT). Data regarding interventions, clinical outcomes, morbidity, and mortality were analyzed with descriptive statistics.

Results

Nine

SUBMITTER: Richardson CM 

PROVIDER: S-EPMC10243723 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature