Dataset Information

Single-Subject TMS Pulse Visualization on MRI-Based Brain Model: A precise method for mapping TMS pulses on cortical surface.

ABSTRACT: Highly accurate visualization of the points of transcranial magnetic stimulation (TMS) application on the brain cortical surface could provide anatomy-specific analysis of TMS effects. TMS is widely used to activate cortical areas with high spatial resolution, and neuronavigation enables site-specific TMS of particular gyrus sites. Precise control of TMS application points is crucial in determining the stimulation effects. Here, we propose a method that gives an opportunity to visualize and analyze the stimulated cortical sites by processing multi-parameter data.•This method uses MRI data to create a participant's brain model for visualization. The MRI data is segmented to obtain a raw 3D model, which is further optimized in 3D modeling software.•A Python script running in Blender uses the TMS coil's orientation data and participant's brain 3D model to define and mark the cortical sites affected by the particular TMS pulse.•The Python script can be easily customized to visualize TMS points task-specifically.

SUBMITTER: Syrov N

PROVIDER: S-EPMC10244693 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Single-Subject TMS Pulse Visualization on MRI-Based Brain Model: A precise method for mapping TMS pulses on cortical surface.

Syrov Nikolay N Mustafina Alfiia A Berkmush-Antipova Artemiy A Yakovlev Lev L Demchinsky Andrey A Petrova Daria D Kaplan Alexander A

MethodsX 20230518

Highly accurate visualization of the points of transcranial magnetic stimulation (TMS) application on the brain cortical surface could provide anatomy-specific analysis of TMS effects. TMS is widely used to activate cortical areas with high spatial resolution, and neuronavigation enables site-specific TMS of particular gyrus sites. Precise control of TMS application points is crucial in determining the stimulation effects. Here, we propose a method that gives an opportunity to visualize and anal ...[more]

PMID: 37292240

Similar Datasets

Project description:Transcranial magnetic stimulation (TMS) with simultaneous electroencephalography applied to the primary motor cortex provides two parameters for cortical excitability: motor evoked potentials (MEPs) and TMS-evoked potentials (TEPs). This study aimed to evaluate the effects of systematic coil shifts on both the TEP N100 component and MEPs in addition to the relationship between both parameters. In 12 healthy adults, the center of a standardized grid was fixed above the hot spot of the target muscle of the left primary motor cortex. Twelve additional positions were arranged in a quadratic grid with positions between 5 and 10 mm from the hot spot. At each of the 13 positions, TMS single pulses were applied. The topographical maximum of the resulting N100 was located ipsilateral and slightly posterior to the stimulation site. A source analysis revealed an equivalent dipole localized more deeply than standard motor cortex coordinates that could not be explained by a single seeded primary motor cortex dipole. The N100 topography might not only reflect primary motor cortex activation, but also sum activation of the surrounding cortex. N100 amplitude and latency decreased significantly during stimulation anterior-medial to the hot spot although MEP amplitudes were smaller at all other stimulation sites. Therefore, N100 amplitudes might be suitable for detecting differences in local cortical excitability. The N100 topography, with its maximum located posterior to the stimulation site, possibly depends on both anatomical characteristics of the stimulated cortex and differences in local excitability of surrounding cortical areas. The less excitable anterior cortex might contribute to a more posterior maximum. There was no correlation between N100 and MEP amplitudes, but a single-trial analysis revealed a trend toward larger N100 amplitudes in trials with larger MEPs. Thus, functionally efficient cortical excitation might increase the probability of higher N100 amplitudes, but TEPs are also generated in the absence of MEPs.

Dataset Information

Single-Subject TMS Pulse Visualization on MRI-Based Brain Model: A precise method for mapping TMS pulses on cortical surface.

Publications

Single-Subject TMS Pulse Visualization on MRI-Based Brain Model: A precise method for mapping TMS pulses on cortical surface.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets