Cross-Protection Induced by Highly Conserved Human B, CD4^+, and CD8⁺ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern.

ABSTRACT:

Background

The Coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of SARS-CoV-2 infections has decreased significantly; the long-term outlook of COVID-19 remains a serious cause of high death worldwide; with the mortality rate still surpassing even the worst mortality rates recorded for the influenza viruses. The continuous emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, have prolonged the COVID-19 pandemic and outlines the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs.

Methods

In the present study, we designed a multi-epitope-based Coronavirus vaccine that incorporated B, CD4

SUBMITTER: Prakash S 

PROVIDER: S-EPMC10245830 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature