Influence of vitamin D supplementation on fracture risk, bone mineral density and bone biochemistry in Mongolian schoolchildren: multicenter double-blind randomized placebo-controlled trial.

ABSTRACT:

Background

Randomized controlled trials (RCT) of vitamin D supplementation to reduce fracture risk in children are lacking.

Methods

We conducted a Phase 3 RCT of weekly oral supplementation with 14,000 IU vitamin D₃ for 3 years in Mongolian schoolchildren aged 6-13 years. Serum 25-hydroxyvitamin D (25[OH]D) concentrations and the proportion of participants reporting ≥1 fracture were secondary outcomes for the main trial. Radial bone mineral density (BMD) was assessed in a nested sub-study, with serum concentrations of parathyroid hormone (PTH) and bone-specific alkaline phosphatase (BALP) determined in a subset of participants.

Findings

8851 children were enrolled in the main trial, of whom 1465 also participated in the sub-study. Vitamin D deficiency was p

SUBMITTER: Ganmaa D 

PROVIDER: S-EPMC10246036 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature