Synthesis of sp³-rich heterocyclic frameworks by a divergent synthesis strategy.

ABSTRACT: Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp³-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development.

SUBMITTER: Mortensen KT 

PROVIDER: S-EPMC10246434 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature