Unknown

Dataset Information

0

Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.

ABSTRACT: Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp3-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development.

SUBMITTER: Mortensen KT 

PROVIDER: S-EPMC10246434 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis of sp<sup>3</sup>-rich heterocyclic frameworks by a divergent synthesis strategy.

Mortensen Kim T KT   Wong Denedy S Y DSY   King Thomas A TA   Sore Hannah F HF   Spring David R DR  

Organic & biomolecular chemistry 20230607 22

Fragment-based lead discovery (FBLD) often relies on flat, aromatic compounds which display undesirable physicochemical properties with limited exit vectors for fragment growth. Herein, we report concise synthetic strategies to sp<sup>3</sup>-rich heterocyclic fragments encompassing polar exit vectors poised for fragment-to-lead (F2L) development. ...[more]

Similar Datasets

Unknown Synthesis and Demonstration of the Biological Relevance of sp<sup>3</sup> -rich Scaffolds Distantly Related to Natural Product Frameworks.
| S-EPMC5703167 | biostudies-literature
Unknown Designed synthesis of stable light-emitting two-dimensional sp<sup>2</sup> carbon-conjugated covalent organic frameworks.
| S-EPMC6175883 | biostudies-literature
Unknown Biocatalytic strategy for the construction of sp<sup>3</sup>-rich polycyclic compounds from directed evolution and computational modelling.
| S-EPMC11088497 | biostudies-literature
Unknown Lewis Acid-Catalyzed Divergent (4+3)/(4+2) Annulations of &lt;i&gt;o&lt;/i&gt;-Quinone Methides with Bicyclo[1.1.0]butanes Lead to sp&lt;sup&gt;3&lt;/sup&gt;-Rich Oxabicyclic Frameworks.
| S-EPMC12836357 | biostudies-literature
Unknown Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp<sup>3</sup> -Rich Compounds With Distinct Phenotypic Effects.
| S-EPMC10946999 | biostudies-literature
Unknown Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp<sup>3</sup>-Rich Morpholine Peptidomimetics.
| S-EPMC6218424 | biostudies-literature
Unknown Rhodium-Catalyzed Diastereo- and Enantioselective Divergent Annulations between Cyclobutanones and 1,5-Enynes: Rapid Construction of Complex C(sp<sup>3</sup>)-Rich Scaffolds.
| S-EPMC10630065 | biostudies-literature
Unknown Enantioselective Synthesis of a Tricyclic, sp<sup>3</sup> -Rich Diazatetradecanedione: an Amino Acid-Based Natural Product-Like Scaffold.
| S-EPMC7187416 | biostudies-literature
Unknown A multi pathway coupled domino strategy: I<sub>2</sub>/TBHP-promoted synthesis of imidazopyridines and thiazoles <i>via</i> sp<sup>3</sup>, sp<sup>2</sup> and sp C-H functionalization.
| S-EPMC8981869 | biostudies-literature
Unknown A divergent enantioselective strategy for the synthesis of griseusins.
| S-EPMC4565752 | biostudies-literature