Associations of VEGF Polymorphisms With Retinopathy of Prematurity.

ABSTRACT:

Purpose

This study investigated the associations between vascular endothelial growth factor (VEGF) polymorphisms and retinopathy of prematurity (ROP) risk.

Methods

Infants born prematurely at any time from 2009 to 2018 were included. Five single-nucleotide polymorphisms (SNPs) of VEGF were analyzed using real-time PCR in all infants. Multivariate logistic regression was applied to model the associations between VEGF polymorphisms and ROP susceptibility, severity, and premature clinicopathologic characteristics.

Results

A total of 334 patients were included and categorized into three groups: those without ROP, those with mild ROP (i.e., ROP not requiring treatment), and those with severe ROP (i.e., ROP for whom treatment was indicated). Among the female patients with R

SUBMITTER: Ling XC 

PROVIDER: S-EPMC10246755 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature