Ontology highlight
ABSTRACT:
SUBMITTER: Teng SW
PROVIDER: S-EPMC10246907 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Teng Shuai-Wen SW Wang Xin-Rong XR Du Bo-Wen BW Chen Xiao-Lin XL Fu Guan-Zhou GZ Liu Yun-Fei YF Xu Shu-Qi SQ Shuai Jia-Chen JC Chen Zhe-Yu ZY
Science advances 20230607 23
It is known that post-retrieval extinction but not extinction alone could erase fear memory. However, whether the coding pattern of original fear engrams is remodeled or inhibited remains largely unclear. We found increased reactivation of engram cells in the prelimbic cortex and basolateral amygdala during memory updating. Moreover, conditioned stimulus- and unconditioned stimulus-initiated memory updating depends on the engram cell reactivation in the prelimbic cortex and basolateral amygdala, ...[more]