Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.

ABSTRACT:

Background

The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.

Methods

We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed th

SUBMITTER: Lindstrom S 

PROVIDER: S-EPMC10248849 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature