Tolerability of bedtime diuretics: a prospective cohort analysis.

ABSTRACT:

Objectives

We sought to validate, or refute, the common belief that bedtime diuretics are poorly tolerated due to nocturia.

Design

Prespecified prospective cohort analysis embedded within the randomised BedMed trial, in which hypertensive participants are randomised to morning versus bedtime antihypertensive administration.

Setting

352 community family practices across 4 Canadian provinces between March 2017 and September 2020.

Participants

552 hypertensive patients (65.6 years old, 57.4% female) already established on a single once-daily morning antihypertensive and randomised to switch that antihypertensive to bedtime. Of these, 203 used diuretics (27.1% thiazide alone, 70.0% thiazide/non-diuretic combinations) and 349 used non-diuretics.

Intervention

SUBMITTER: Garrison SR 

PROVIDER: S-EPMC10255011 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature