Unknown

Dataset Information

0

Bidirectionality between cardiometabolic diseases and COVID-19: Role of humoral immunity.


ABSTRACT: Cardiometabolic diseases and abnormalities have recently emerged as independent risk factors of coronavirus disease 2019 (COVID-19) severity, including hospitalizations, invasive mechanical ventilation, and mortality. Determining whether and how this observation translates to more effective long-term pandemic mitigation strategies remains a challenge due to key research gaps. Specific pathways by which cardiometabolic pathophysiology affects humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), and vice versa, remain unclear. This review summarizes current evidence of the bidirectional influences between cardiometabolic diseases (diabetes, adiposity, hypertension, cardiovascular diseases) and SARS-CoV-2 antibodies induced from infection and vaccination based on human studies. Ninety-two studies among >408,000 participants in 37 countries on 5 continents (Europe, Asia, Africa, North and South America) were included in this review. Obesity was associated with higher neutralizing antibody titers following SARS-CoV-2 infection. Most studies conducted prior to vaccinations found positive or null associations between binding antibodies (levels, seropositivity) and diabetes; after vaccinations, antibody responses did not differ by diabetes. Hypertension and cardiovascular diseases were not associated with SARS-CoV-2 antibodies. Findings underscore the importance of elucidating the extent that tailored recommendations for COVID-19 prevention, vaccination effectiveness, screening, and diagnoses among people with obesity could reduce disease burden caused by SARS-CoV-2.

SUBMITTER: Yu EA 

PROVIDER: S-EPMC10256583 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity.

Yu Elaine A EA   Jackman Rachael P RP   Glesby Marshall J MJ   Narayan Km Venkat KV  

Advances in nutrition (Bethesda, Md.) 20230610 5


Cardiometabolic diseases and abnormalities have recently emerged as independent risk factors of coronavirus disease 2019 (COVID-19) severity, including hospitalizations, invasive mechanical ventilation, and mortality. Determining whether and how this observation translates to more effective long-term pandemic mitigation strategies remains a challenge due to key research gaps. Specific pathways by which cardiometabolic pathophysiology affects humoral immunity against severe acute respiratory synd  ...[more]

Similar Datasets

| S-EPMC9965425 | biostudies-literature
| S-EPMC9539352 | biostudies-literature
| S-EPMC10764151 | biostudies-literature
| S-EPMC10792913 | biostudies-literature
| S-EPMC8943686 | biostudies-literature
| S-EPMC8132219 | biostudies-literature
| S-EPMC8245343 | biostudies-literature
| S-EPMC9418484 | biostudies-literature
| S-EPMC9375081 | biostudies-literature
| S-EPMC8570443 | biostudies-literature