DNA methylation alterations at RE1-silencing transcription factor binding sites and their flanking regions in cancer.

ABSTRACT:

Background

DNA methylation changes, frequent early events in cancer, can modulate the binding of transcription factors. RE1-silencing transcription factor (REST) plays a fundamental role in regulating the expression of neuronal genes, and in particular their silencing in non-neuronal tissues, by inducing chromatin modifications, including DNA methylation changes, not only in the proximity of its binding sites but also in the flanking regions. REST has been found aberrantly expressed in brain cancer and other cancer types. In this work, we investigated DNA methylation alterations at REST binding sites and their flanking regions in a brain cancer (pilocytic astrocytoma), two gastrointestinal tumours (colorectal cancer and biliary tract cancer) and a blood cancer (chronic lymphocytic

SUBMITTER: Vega-Benedetti AF 

PROVIDER: S-EPMC10257853 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature