Ontology highlight
ABSTRACT:
SUBMITTER: Gordan R
PROVIDER: S-EPMC3640701 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cell reports 20130404 4
DNA sequence is a major determinant of the binding specificity of transcription factors (TFs) for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with highly similar DNA binding motifs but distinct in vivo targets. Currently, it is not well understood how TFs with seemingly identical DNA motifs achieve unique specificities in vivo. Here, we used custom protein-binding microarrays to analyze TF specificity for putative binding sites in their genomic sequence ...[more]