A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation.

ABSTRACT:

Background

Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help improve longterm outcomes. Here, we studied the impact of a non-muscle myosin heavy chain 9 gene (MYH9) polymorphism on allograft failure.

Methods

We conducted an observational cohort study, analyzing the DNA of 1,271 kidney donor-recipient transplant pairs from a single academic hospital for the MYH9 rs11089788 C>A polymorphism. The associations of the MYH9 genotype with risk of graft failure, biopsy-proven acute rejection (BPAR), and delayed graft function (DGF) were estimated.

Results

A trend was seen in the association

SUBMITTER: Poppelaars F 

PROVIDER: S-EPMC10265209 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature