Ontology highlight
ABSTRACT:
SUBMITTER: Cornachione AS
PROVIDER: S-EPMC4126752 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cornachione Anabelle S AS Leite Felipe S FS Wang Junling J Leu Nicolae A NA Kalganov Albert A Volgin Denys D Han Xuemei X Xu Tao T Cheng Yu-Shu YS Yates John R R JR Rassier Dilson E DE Kashina Anna A
Cell reports 20140710 2
Protein arginylation is a posttranslational modification with an emerging global role in the regulation of actin cytoskeleton. To test the role of arginylation in the skeletal muscle, we generated a mouse model with Ate1 deletion driven by the skeletal muscle-specific creatine kinase (Ckmm) promoter. Ckmm-Ate1 mice were viable and outwardly normal; however, their skeletal muscle strength was significantly reduced in comparison to controls. Mass spectrometry of isolated skeletal myofibrils showed ...[more]