Dataset Information

Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.

ABSTRACT:

Objective

Central-positive complexes (CPCs) are elicited during electroconvulsive therapy (ECT) as generalized high-amplitude waveforms with maximum positive voltage over the vertex. While these complexes have been qualitatively assessed in previous literature, quantitative analyses are lacking. This study aims to characterize CPCs across temporal, spatial, and spectral domains.

Methods

High-density 64-electrode electroencephalogram (EEG) recordings during 50 seizures acquired from 11 patients undergoing right unilateral ECT allowed for evaluation of spatiotemporal characteristics of CPCs via source localization and spectral analysis.

Results

Peak-amplitude CPC scalp topology was consistent across seizures, showing maximal positive polarity over the midline fronto-central region and maximal negative polarity over the suborbital regions. The sources of these peak potentials were localized to the bilateral medial thalamus and cingulate cortical regions. Delta, beta, and gamma oscillations were correlated with the peak amplitude of CPCs during seizures induced during ketamine, whereas delta and gamma oscillations were associated with CPC peaks during etomidate anesthesia (excluding the dose-charge titration).

Conclusions

Our findings demonstrate the consistency of CPC presence across participant, stimulus charge, time, and anesthetic agent, with peaks localized to bilateral medial thalamus and cingulate cortical regions and associated with delta, beta, and gamma band oscillations (depending on the anesthetic condition).

Significance

The consistency and reproducibility of CPCs offers ECT as a new avenue for studying the dynamics of generalized seizure activity and thalamocortical networks.

SUBMITTER: Huels ER

PROVIDER: S-EPMC10273093 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.

Huels Emma R ER Kafashan MohammadMehdi M Hickman L Brian LB Ching ShiNung S Lin Nan N Lenze Eric J EJ Farber Nuri B NB Avidan Michael S MS Hogan R Edward RE Palanca Ben Julian A BJA

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20221209

<h4>Objective</h4>Central-positive complexes (CPCs) are elicited during electroconvulsive therapy (ECT) as generalized high-amplitude waveforms with maximum positive voltage over the vertex. While these complexes have been qualitatively assessed in previous literature, quantitative analyses are lacking. This study aims to characterize CPCs across temporal, spatial, and spectral domains.<h4>Methods</h4>High-density 64-electrode electroencephalogram (EEG) recordings during 50 seizures acquired fro ...[more]

PMID: 36549264

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Dataset Information

Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.

Objective

Methods

Results

Conclusions

Significance

Publications

Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.

Similar Datasets

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