Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

ABSTRACT: Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon with sharply rising global prevalence. Dysfunctional epithelial compartment (EC) dynamics are implicated in UC pathogenesis although EC-specific studies are sparse. Applying orthogonal high-dimensional EC profiling to a Primary Cohort (PC; n=222), we detail major epithelial and immune cell perturbations in active UC. Prominently, reduced frequencies of mature BEST4⁺OTOP2⁺ absorptive and BEST2⁺WFDC2⁺ secretory epithelial enterocytes were associated with the replacement of homeostatic, resident TRDC⁺KLRD1⁺HOPX⁺ γδ⁺ T cells with RORA⁺CCL20⁺<

SUBMITTER: Jha D 

PROVIDER: S-EPMC10274630 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature