Catalytic growth in a shared enzyme pool ensures robust control of centrosome size.

ABSTRACT: Accurate regulation of centrosome size is essential for ensuring error-free cell division, and dysregulation of centrosome size has been linked to various pathologies, including developmental defects and cancer. While a universally accepted model for centrosome size regulation is lacking, prior theoretical and experimental works suggest a centrosome growth model involving autocatalytic assembly of the pericentriolar material. Here we show that the autocatalytic assembly model fails to explain the attainment of equal centrosome sizes, which is crucial for error-free cell division. Incorporating latest experimental findings into the molecular mechanisms governing centrosome assembly, we introduce a new quantitative theory for centrosome growth involving catalytic assembly within a shared poo

SUBMITTER: Banerjee DS 

PROVIDER: S-EPMC10274694 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature