Ontology highlight
ABSTRACT:
SUBMITTER: Salamzade R
PROVIDER: S-EPMC10274777 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Salamzade Rauf R Tran Patricia Q PQ Martin Cody C Manson Abigail L AL Gilmore Michael S MS Earl Ashlee M AM Anantharaman Karthik K Kalan Lindsay R LR
bioRxiv : the preprint server for biology 20240912
Many universally and conditionally important genes are genomically aggregated within clusters. Here, we introduce fai and zol, which together enable large-scale comparative analysis of different types of gene clusters and mobile-genetic elements (MGEs), such as biosynthetic gene clusters (BGCs) or viruses. Fundamentally, they overcome a current bottleneck to reliably perform comprehensive orthology inference at large scale across broad taxonomic contexts and thousands of genomes. First, fai allo ...[more]