Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors.

ABSTRACT: An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making-related disorders, including addiction. Although external globus pallidus (GPe) is critical for action selection, which harbors enriched astrocytes, the role of GPe astrocytes involved in action-selection strategies remained unknown. Using in vivo calcium signaling with fiber photometry, we found substantially attenuated GPe astrocytic activity during habitual learning compared to goal-directed learning. The support vector machine analysis predicted the behavioral outcomes. Chemogenetic activation of the astrocytes or inhibition of GPe pan-neuronal activities facilitates the transition from habit to goal-directed reward-seeking behavior. Next, we found increased astrocyte-specific GABA (γ-aminobu

SUBMITTER: Kang S 

PROVIDER: S-EPMC10275597 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature