Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.

ABSTRACT: Neurons enhance their computational power by combining linear and nonlinear transformations in extended dendritic trees. Rich, spatially distributed processing is rarely associated with individual synapses, but the cone photoreceptor synapse may be an exception. Graded voltages temporally modulate vesicle fusion at a cone's ~20 ribbon active zones. Transmitter then flows into a common, glia-free volume where bipolar cell dendrites are organized by type in successive tiers. Using super-resolution microscopy and tracking vesicle fusion and postsynaptic responses at the quantal level in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus, we show that certain bipolar cell types respond to individual fusion events in the vesicle stream while other types respond to degrees of locally

SUBMITTER: Grabner CP 

PROVIDER: S-EPMC10276006 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature