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Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics.

ABSTRACT: Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.

SUBMITTER: Kikuchi H

PROVIDER: S-EPMC10276015 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics.

Kikuchi Hiroaki H Chou Chung-Lin CL Yang Chin-Rang CR Chen Lihe L Jung Hyun Jun HJ Park Euijung E Limbutara Kavee K Carter Benjamin B Yang Zhi-Hong ZH Kun Julia F JF Remaley Alan T AT Knepper Mark A MA

Nature communications 20230616 1

Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubu ...[more]

PMID: 37328470

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