Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics.

ABSTRACT: Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.

SUBMITTER: Kikuchi H 

PROVIDER: S-EPMC10276015 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature