A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue.

ABSTRACT:

Background

Peripheral vascular disease remains a leading cause of vascular morbidity and mortality worldwide despite advances in medical and surgical therapy. Besides traditional approaches, which can only restore blood flow to native arteries, an alternative approach is to enhance the growth of new vessels, thereby facilitating the physiological response to ischemia.

Methods

The Actin^CreER/R26^VT2/GK3 Rainbow reporter mouse was used for unbiased in vivo survey of injury-responsive vasculogenic clonal formation. Prospective isolation and transplantation were used to determine vessel-forming capacity of different populations. Single-cell RNA-sequencing was used to characterize distinct vessel-forming populations and their interactions.

Results

Two

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10281192 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature