Development of a candidate multi-epitope vaccine against Sphingobacterium spiritivorum : Reverse vaccinology and immunoinformatics approach.

ABSTRACT:

Objectives

To develop a candidate vaccine aginst the Sphingobacterium spiritivorum.

Methods

Since there is currently no vaccine against this pathogen, we employed in-silico methods to extensively explore the outer membrane toxin-producing proteins found specifically in S. spiritivorum to forecast a multi-epitope chimeric vaccine design. This computational study was conducted in Saudi Arabia in 2022 (study design: computational; ethical approval not applicable).

Results

TThe vaccine peptide comprises multiple linear and conformational B-cell epitopes, which have the potential to elicit humoral immunity. Projected B-cell- derived T-cell epitopes for outer membrane proteins are present in the produced protein. The docking and molecular dynamic simulation re

SUBMITTER: Alamri MA 

PROVIDER: S-EPMC10284220 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature