Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis.

ABSTRACT:

Background

Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness. AU remission has been observed in pregnant female patients. However, the effects of progesterone (PRG), a critical hormone for reproduction, on the treatment of AU and the regulatory mechanisms remain unclear.

Methods

To this end, we established experimental autoimmune uveitis (EAU) animal models and constructed a high-dimensional immune atlas of EAU-model mice undergoing PRG treatment to explore the underlying therapeutic mechanisms of PRG using single-cell RNA sequencing.

Results

We found that PRG ameliorated retinal lesions and inflammatory infiltration in EAU-model mice. Further single-cell

SUBMITTER: Liu X 

PROVIDER: S-EPMC10286326 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature