Ontology highlight
ABSTRACT:
SUBMITTER: Sakai E
PROVIDER: S-EPMC10290684 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Sakai Eiko E Imaizumi Tsutomu T Suzuki Ruruka R Taracena-Gándara Marcos M Fujimoto Toshiki T Sakurai Fuminori F Mizuguchi Hiroyuki H
Communications biology 20230624 1
Non-alcoholic liver disease (NAFLD) is a condition caused by excessive fat accumulation in the liver and developed via multiple pathways. miR-27b has been suggested to play crucial roles in the development of NAFLD, assuming via targeting genes involved in lipid catabolism and anabolism. However, other pathways regulated by miR-27b are largely unknown. Here we show that lipid accumulation was induced in miR-27b-transfected human and mouse hepatic cells and that knockdowns of three miR-27b-target ...[more]