NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
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ABSTRACT:
SUBMITTER: Tran LS
PROVIDER: S-EPMC10293252 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
Tran L S LS Ying L L D'Costa K K Wray-McCann G G Kerr G G Le L L Allison C C CC Ferrand J J Chaudhry H H Emery J J De Paoli A A Colon N N Creed S S Kaparakis-Liaskos M M Como J J Dowling J K JK Johanesen P A PA Kufer T A TA Pedersen J S JS Mansell A A Philpott D J DJ Elgass K D KD Abud H E HE Nachbur U U Croker B A BA Masters S L SL Ferrero R L RL
Nature communications 20230626 1
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined, those involved in IL-18 processing, particularly in non-myeloid cells, are still not well understood. Here we report that the host defence molecule NOD1 regulates IL-18 processing in mouse epithelial cells in response to the mucosal pathogen, He ...[more]
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