Human papillomavirus integration transforms chromatin to drive oncogenesis.

ABSTRACT:

Background

Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at the location of integration can result in changes in gene expression that contribute to the tumorigenicity of HPV.

Results

We find that viral integration events often occur along with changes in chromatin state and expression of genes near the integration site. We investigate whether introduction of new transcription factor binding sites due to HPV integration could invoke these changes. Some regions within the HPV genome, particularly the position of a conserved CTCF binding site, show enriched chromatin accessibility signa

SUBMITTER: Karimzadeh M 

PROVIDER: S-EPMC10294493 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature