Cerebrospinal Fluid Chloride Is Associated with Disease Activity of Relapsing-Remitting Multiple Sclerosis: A Retrospective Cohort Study.

ABSTRACT:

Background

Blood-brain barrier dysfunction in active multiple sclerosis (MS) lesions leads to pathological changes in the cerebrospinal fluid (CSF). This study aimed to investigate the possible association between routine CSF findings, especially CSF chloride, at the time of the first lumbar puncture and the relapse risk and disability progression of relapsing-remitting MS (RRMS).

Methods

This retrospective study included 77 patients with RRMS at the MS Center of our institution from January 2012 to December 2020. The Anderson and Gill (AG) model and Spearman correlation analysis were used to explore predictors of relapse and disability during follow-up.

Results

In the multivariate AG model, patients with elevated CSF chloride level (hazard ratio [HR], 1.1; 95% confid

SUBMITTER: Fang X 

PROVIDER: S-EPMC10296568 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature