Dataset Information

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [^99mTc]Tc-ADAPT6 and [^99mTc]Tc-(HE)₃-G3, for Imaging of HER2-Positive Breast Cancer.

ABSTRACT: Previous Phase I clinical evaluations of the radiolabelled scaffold proteins [^99mTc]Tc-ADAPT6 and DARPin [^99mTc]Tc-(HE)₃-G3 in breast cancer patients have demonstrated their safety and indicated their capability to discriminate between HER2-positive and HER2-negative tumours. The objective of this study was to compare the imaging of HER2-positive tumours in the same patients using [^99mTc]Tc-ADAPT6 and [^99mTc]Tc-(HE)₃-G3. Eleven treatment-naïve female patients (26-65 years) with HER2-positive primary and metastatic breast cancer were included in the study. Each patient was intravenously injected with [^99mTc]Tc-ADAPT6, followed by an [^99mTc]Tc-(HE)₃-G3 injection 3-4 days later and chest SPECT/C

SUBMITTER: Bragina O

PROVIDER: S-EPMC10296685 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Dataset Information

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [^99mTc]Tc-ADAPT6 and [^99mTc]Tc-(HE)₃-G3, for Imaging of HER2-Positive Breast Cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3, for Imaging of HER2-Positive Breast Cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [^99mTc]Tc-ADAPT6 and [^99mTc]Tc-(HE)₃-G3, for Imaging of HER2-Positive Breast Cancer.