Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration.

ABSTRACT:

Objective

Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to spare glucose. We hypothesized that persistent stimulation of lipolysis during glucocorticoid therapy plays a causative role in the development of iatrogenic diabetes.

Methods

Male C57BL/6J mice were given 100 μg/mL corticosterone (Cort) in the drinking water for two weeks and were fed either normal chow (TekLad 8640) or the same diet supplemented with an adipose triglyceride lipase inhibitor (Atglistatin - 2  g/kg diet) to inhibit the first step of lipolysis.

Results

Herein, we report for the first time that glucocorticoi

SUBMITTER: Linden MA 

PROVIDER: S-EPMC10300254 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature