Ontology highlight
ABSTRACT:
SUBMITTER: Bengtsson C
PROVIDER: S-EPMC10304315 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Bengtsson Christoffer C Gravenfors Ylva Y
Molecules (Basel, Switzerland) 20230616 12
The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient synthesis of a type of duocarmycin prodrug. The 1,2,3,6-tetrahydropyrrolo[3,2-<i>e</i>]indole-containing core is here constructed from commercially available Boc-5-bromoindole in four steps and 23% overall yield, utilizing a Buchwald-Hartwig amination followed by a sodium hydride-induced regioselective bromination. In addition, protocols ...[more]