Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women.

ABSTRACT:

Background

Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results indicate effect of low-dose tamoxifen therapy. Using questionnaire data from a randomised controlled trial, we describe side effects of standard and low-dose tamoxifen in healthy women.

Methods

In the KARISMA trial, 1440 healthy women were randomised to 6 months of daily intake of 20, 10, 5, 2.5, 1 mg of tamoxifen or placebo. Participants completed a 48-item, five-graded Likert score symptom questionnaire at baseline and follow-up. Linear regression models were used to identify significant changes in severity levels across doses and by menopausal status.

Results

Out of 48 predefined symptoms, five were associated with tamoxife

SUBMITTER: Hammarstrom M 

PROVIDER: S-EPMC10307785 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature