Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.

ABSTRACT: Migraine is a common and complex neurological disease potentially caused by a polygenic interaction of multiple gene variants. Many genes associated with migraine are involved in pathways controlling the synaptic function and neurotransmitters release. However, the molecular mechanisms underpinning migraine need to be further explored.Recent studies raised the possibility that migraine may arise from the effect of regulatory non-coding variants. In this study, we explored the effect of candidate non-coding variants potentially associated with migraine and predicted to lie within regulatory elements: VAMP2_rs1150, SNAP25_rs2327264, and STX1A_rs6951030. The involvement of these genes, which are constituents of the SNARE complex involved in membrane fusion and neurotransmitter release, unders

SUBMITTER: Felicio D 

PROVIDER: S-EPMC10308609 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature