The association of prediabetes and type 2 diabetes with hippocampal subfields volume: The Maastricht study.

ABSTRACT:

Aims/hypothesis

We investigated whether prediabetes, type 2 diabetes, and continuous measures of hyperglycemia are associated with tissue volume differences in specific subfields of the hippocampus.

Methods

We used cross-sectional data from 4,724 participants (58.7 ± 8.5 years, 51.5% women) of The Maastricht Study, a population-based prospective cohort. Glucose metabolism status was assessed with an oral glucose tolerance test, and defined as type 2 diabetes (n = 869), prediabetes (n = 671), or normal glucose metabolism (n = 3184). We extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using T1w and FLAIR 3T MRI images. We used multiple linear regression and linear trend analysis, and adjusted for total intracranial volume, demographic, lifestyle, a

SUBMITTER: Monereo-Sanchez J 

PROVIDER: S-EPMC10310479 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature