Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.

ABSTRACT: Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide across cell membranes, and these lipids or their metabolites play important roles in signal transduction pathways regulating metabolism. However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A knockout mice and show that Atp10A^-/- mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. However, Atp10A^-/- mice displayed female-specific dyslipidemia characterized by elevated plasma triglycerides, free fatty acids and

SUBMITTER: Norris AC 

PROVIDER: S-EPMC10312798 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature