Accumulated X-ray irradiation induces miR-187-5p upregulation mediating fibrotic buccal mucosal fibroblasts activities via DKK2

ABSTRACT:

Background/purpose

With the wide application of X-rays in dental examinations, it is necessary to assess its potential risk and explore an effective indicator. This study aimed to analyze the response of miR-187-5p to X-ray irradiation and to evaluate its potential of predicting X-ray potential dangers.

Materials and methods

Patients that had to receive dental X-ray examination were enrolled and the expression of miR-187-5p in the buccal mucosa swabs were detected by real-time quantitative polymerase chain reaction (PCR). The effect of miR-187-5p on fibrotic buccal mucosal fibroblasts (fBMFs) activities was assessed by cell migration and invasion and the expression of fibrosis markers. In mechanism, the interaction between miR-187-5p and DKK2 and their co-regulatory effec

SUBMITTER: Zheng G 

PROVIDER: S-EPMC10316441 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature