Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across 10 cross-sectional microbiome datasets and 15 other datasets, including dietary patterns, metabolomics, cytokine profiles and human brain gene expression profiles. We found a functional architecture along the GBA that correlates with heterogeneity of ASD phenotypes, and it is characterized by ASD-associated amino acid, carbohydrate and lipid profiles predominantly encoded by microbial species in t

SUBMITTER: Morton JT 

PROVIDER: S-EPMC10322709 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature