Diagnostic challenges of hypoganglionosis based on immunohistochemical method.

ABSTRACT:

Background

Hypoganglionosis resembles Hirschsprung's disease as in both diseases, patients may present with severe constipation or pseudo-obstruction. To date, diagnosis of hypoganglionosis is still difficult to be established due to lack of international consensus regarding diagnostic criteria. This study aims to evaluate the use of immunohistochemistry to provide objective support for our initial subjective impression of hypoganglionosis as well as to describe the morphological features of this study.

Methods

This is a cross-sectional study. Three resected intestinal samples from patients with hypoganglionosis at Kyushu University Hospital, Fukuoka, Japan were included in this study. One healthy intestinal sample was used as control. All specimens were immunohistochemicall

SUBMITTER: Alatas FS 

PROVIDER: S-EPMC10326751 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature