Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest.

ABSTRACT: Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had less evidence of cardiac and renal damage after cardiac arrest when compared to those not taking metformin. Based on these observations, we hypothesized that metformin's protective effects in the heart were mediated by AMPK signaling, and that AMPK signaling could be targeted as a therapeutic strategy following resuscitation from CA. The current study investigates metformin interventions on cardiac and renal outcomes in a non-diabetic CA mouse model. We found that two weeks of metformin pretreatment protects against reduced ejection fraction and reduces k

SUBMITTER: Rutledge CA 

PROVIDER: S-EPMC10327679 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature